Methods and studies


HRVanalysis 1.0

Pichot V, Roche F, Celle S, Barthélémy JC, Chouchou F. HRVanalysis: a free software for analyzing cardiac autonomic activity. Front. Physiol. 22 November 2016.


Methodological references

Rajendra Acharya, U., Paul Joseph, K., Kannathal, N., Lim, C. M., and Suri, J. S. (2006). Heart rate variability: a review. Med. Biol. Eng. Comput. 44, 1031–1051.

European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Eur Heart J. 1996;17(3):354-81.


Principal references from our group linked to HRVanalysis software

Berger M, Raffin J, Pichot V, Hupin D, Garet M, Labeix P, Costes F, Barthélémy JC, Roche F. Effect of exercise training on heart rate variability in patients with obstructive sleep apnea: A randomized controlled trial. Scand J Med Sci Sports. 2019 May 2. doi: 10.1111/sms.13447. [Epub ahead of print]

Patural H, Pichot V, Flori S, Giraud A, Franco P, Pladys P, Beuchée A, Roche F, Barthelemy JC. Autonomic maturation from birth to 2 years: normative values. Heliyon. 2019 Mar 7;5(3):e01300. doi: 10.1016/j.heliyon.2019.e01300. eCollection 2019 Mar.

Venet T, Pichot V, Charier D, Scalabre A, Patural H. Autonomic cardiac regulation after general anesthesia in children. Paediatr Anaesth. 2018 Oct;28(10):881-887. doi: 10.1111/pan.13468.

Berger C, Casagranda L, Pichot V, Trombert-Paviot B, Faure-Conter C, Freycon C, Isfan F, Guichard I, Durieu I, Garcin A, Roche F, Patural H. Dysautonomia in Childhood Cancer Survivors: A Widely Underestimated Risk. J Adolesc Young Adult Oncol. 2018 Aug 23. doi: 10.1089/jayao.2018.0021. [Epub ahead of print]

Fauchon C, Pichot V, Faillenot I, Pommier B, Garcia-Larrea L, Peyron R, Chouchou F. Contextual modulation of autonomic pain reactivity. Auton Neurosci. 2018 Jul;212:28-31. doi: 10.1016/j.autneu.2018.04.002. Epub 2018 Apr 10.

Cremillieux C, Makhlouf A, Pichot V, Trombert B, Patural H. Objective assessment of induced acute pain in neonatology with the Newborn Infant Parasympathetic Evaluation index. Eur J Pain. 2018 Jul;22(6):1071-1079. doi: 10.1002/ejp.1191. Epub 2018 Mar 24.

Fauchon C, Faillenot I, Perrin AM, Borg C, Pichot V, Chouchou F, Garcia-Larrea L, Peyron R. Does an observer's empathy influence my pain ? Effect of perceived empathetic or unempathetic support in a pain test. Eur J Neurosci. 2017 Nov;46(10):2629-2637. doi: 10.1111/ejn.13701. Epub 2017 Oct 19.

Chouchou F, Bouet R, Pichot V, Catenoix H, Mauguière F, Jung J. The neural bases of ictal tachycardia in temporal lobe seizures. Clin Neurophysiol. 2017 Sep;128(9):1810-1819. 

Sforza E, Roche F, Barthélémy JC, Pichot V. Diurnal ans nocturnal cardiovascular variability and heart rate arousal response in idiopathic hypersomnia. Sleep Med. 2016 Aug;24:131-136.

Chalencon S, Pichot V, Roche F, Lacour JR, Garet M, Connes P, Barthélémy JC, Busso T. Modeling of performance and ANS activity for predicting future responses to training. Eur J Appl Physiol. 2015 Mar;115(3):589-96.

Sforza E, Pichot V, Gschwind M, Roche F, Maeder-Ingvar M. Bradycardia and asystole during generalised interictal EEG discharges. Epileptic Disord. 2014 Dec;16(4):506-9.

Chouchou F, Pichot V, Barthélémy JC, Bastuji H, Roche F. Cardiac sympathetic modulation in response to apneas/hypopneas through heart rate variability analysis. PLoS One. 2014 Jan 22;9(1).

Chouchou F, Pichot V, Pépin JL, Tamisier R, Celle S, Maudoux D, Garcin A, Lévy P, Barthélémy JC, Roche F; PROOF Study Group. Sympathetic overactivity due to sleep fragmentation is associated with elevated diurnal systolic blood pressure in healthy elderly subjects: the PROOF-SYNAPSE study. Eur Heart J. 2013;34(28):2122-31.

Chalencon S, Busso T, Lacour JR, Garet M, Pichot V, Connes P, Gabel CP, Roche F, Barthélémy JC. A model for the training effects in swimming demonstrates a strong relationship between parasympathetic activity, performance and index of fatigue. PLoS One. 2012;7(12).

Sforza E, Chouchou F, Pichot V, Barthélémy JC, Roche F. Heart rate increment in the diagnosis of obstructive sleep apnoea in an older population. Sleep Med. 2012 Jan;13(1):21-8.

Chouchou F, Pichot V, Perchet C, Legrain V, Garcia-Larrea L, Roche F, Bastuji H. Autonomic pain responses during sleep: a study of heart rate variability. Eur J Pain. 2011 Jul;15(6):554-60.

Assoumou HG, Pichot V, Barthelemy JC, Dauphinot V, Celle S, Gosse P, Kossovsky M, Gaspoz JM, Roche F. Metabolic syndrome and short-term and long-term heart rate variability in elderly free of clinical cardiovascular disease: the PROOF study. Rejuvenation Res. 2010;13(6):653-63.

Chouchou F, Pichot V, Garet M, Barthélémy JC, Roche F. Dominance in cardiac parasympathetic activity during real recreational SCUBA diving. Eur J Appl Physiol. 2009 Jun;106(3):345-52

Patural H, Pichot V, Jaziri F, Teyssier G, Gaspoz JM, Roche F, Barthelemy JC. Autonomic cardiac control of very preterm newborns: a prolonged dysfunction. Early Hum Dev. 2008 Oct;84(10):681-7.

Sforza E, Pichot V, Cervena K, Barthélémy JC, Roche F. Cardiac variability and heart-rate increment as a marker of sleep fragmentation in patients with a sleep disorder: a preliminary study. Sleep. 2007 Jan;30(1):43-51.

Roche F, Celle S, Pichot V, Barthélémy JC, Sforza E. Analysis of the interbeat interval increment to detect obstructive sleep apnoea/hypopnoea. Eur Respir J. 2007 Jun;29(6):1206-11.

Garet M, Degache F, Pichot V, Duverney D, Costes F, DA Costa A, Isaaz K, Lacour JR, Barthélémy JC, Roche F.Relationship between daily physical activity and ANS activity in patients with CHF. Med Sci Sports Exerc. 2005 Aug;37(8):1257-63.

Pichot V, Roche F, Denis C, Garet M, Duverney D, Costes F, Barthélémy JC. Interval training in elderly men increases both heart rate variability and baroreflex activity. Clin Auton Res. 2005;15(2):107-15.

Patural H, Barthelemy JC, Pichot V, Mazzocchi C, Teyssier G, Damon G, Roche F. Birth prematurity determines prolonged autonomic nervous system immaturity. Clin Auton Res. 2004 Dec;14(6):391-5.

Roche F, Pichot V, Sforza E, Court-Fortune I, Duverney D, Costes F, Garet M, Barthélémy JC. Predicting sleep apnoea syndrome from heart period: a time-frequency wavelet analysis. Eur Respir J. 2003 Dec;22(6):937-42.

Pichot V, Busso T, Roche F, Garet M, Costes F, Duverney D, Lacour JR, Barthélémy JC. Autonomic adaptations to intensive and overload training periods: a laboratory study. Med Sci Sports Exerc. 2002 Oct;34(10):1660-6.

Pichot V, Gaspoz JM, Molliex S, Antoniadis A, Busso T, Roche F, Costes F, Quintin L, Lacour JR, Barthélémy JC. Wavelet transform to quantify heart rate variability and to assess its instantaneous changes. J Appl Physiol (1985). 1999 Mar;86(3):1081-91.