Publications

HRVanalysis 1.0

Pichot V, Roche F, Celle S, Barthélémy JC, Chouchou F. HRVanalysis: a free software for analyzing cardiac autonomic activity. Front. Physiol. 22 November 2016. http://dx.doi.org/10.3389/fphys.2016.00557

CVRanalysis 1.0

Pichot V, Corbier C, Chouchou F, Barthélémy JC, Roche F. CVRanalysis: a free software for analyzing cardiac, vascular and respiratory interactions. Front. Physiol. 4 january 2024. https://doi.org/10.3389/fphys.2023.1224440

Methodological references

Rajendra Acharya, U., Paul Joseph, K., Kannathal, N., Lim, C. M., and Suri, J. S. (2006). Heart rate variability: a review. Med. Biol. Eng. Comput. 44, 1031–1051.

European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Eur Heart J. 1996;17(3):354-81.

Bauer A, Morley-Davies A, Barthel P, Muller A, Ulm K, Malik M, Schmidt G. Bivariate phase-rectified signal averaging for assessment of spontaneous baroreflex sensitivity: Pilot study of the technology. Journal of electrocardiology. 2010;43:649-653

Corbier C, Chouchou F, Roche F, Barthélémy JC, Pichot V. Causal analyses to study autonomic regulation during acute head-out water immersion, head-down tilt and supine position. Experimental Physiology. 2020 Aug;105(8):1216-1222

Di Rienzo M, Parati G, Castiglioni P, Tordi R, Mancia G, Pedotti A. Baroreflex effectiveness index: An additional measure of baroreflex control of heart rate in daily life. American journal of physiology. Regulatory, integrative and comparative physiology. 2001;280:R744-751

Hughson RL, Quintin L, Annat G, Yamamoto Y, Gharib C. Spontaneous baroreflex by sequence and power spectral methods in humans. Clinical physiology (Oxford, England). 1993;13:663-676

Muller A, Morley-Davies A, Barthel P, Hnatkova K, Bauer A, Ulm K, Malik M, Schmidt G. Bivariate phase-rectified signal averaging for assessment of spontaneous baroreflex sensitivity: Normalization of the results. Journal of electrocardiology. 2012;45:77-81

Pagani M, Somers V, Furlan R, Dell'Orto S, Conway J, Baselli G, Cerutti S, Sleight P, Malliani A. Changes in autonomic regulation induced by physical training in mild hypertension. Hypertension (Dallas, Tex. : 1979). 1988;12:600-610

Parlow J, Viale JP, Annat G, Hughson R, Quintin L. Spontaneous cardiac baroreflex in humans. Comparison with drug-induced responses. Hypertension (Dallas, Tex. : 1979). 1995;25:1058-1068

Porta A, Castiglioni P, Di Rienzo M, Bassani T, Bari V, Faes L, Nollo G, Cividjan A & Quintin L (2013). Cardiovascular control and time domain Granger causality: insights from selective autonomic blockade. Philos Trans A Math Phys Eng Sci 371, 20120161

Pinna GD, Maestri R. Reliability of transfer function estimates in cardiovascular variability analysis. Medical & biological engineering & computing. 2001;39:338-347

Pinna GD, Maestri R, La Rovere MT. Assessment of baroreflex sensitivity from spontaneous oscillations of blood pressure and heart rate: Proven clinical value? Physiological measurement. 2015;36:741-753

Pinna GD, Maestri R, Raczak G, La Rovere MT. Measuring baroreflex sensitivity from the gain function between arterial pressure and heart period. Clinical science (London, England : 1979). 2002;103:81-88Robbe HW, Mulder LJ, Ruddel H, Langewitz WA, Veldman JB, Mulder G. Assessment of baroreceptor reflex sensitivity by means of spectral analysis. Hypertension (Dallas, Tex. : 1979). 1987;10:538-543

Principal references from our group linked to HRVanalysis software

Berger M, Raffin J, Pichot V, Hupin D, Garet M, Labeix P, Costes F, Barthélémy JC, Roche F. Effect of exercise training on heart rate variability in patients with obstructive sleep apnea: A randomized controlled trial. Scand J Med Sci Sports. 2019 May 2. doi: 10.1111/sms.13447. [Epub ahead of print]

Patural H, Pichot V, Flori S, Giraud A, Franco P, Pladys P, Beuchée A, Roche F, Barthelemy JC. Autonomic maturation from birth to 2 years: normative values. Heliyon. 2019 Mar 7;5(3):e01300. doi: 10.1016/j.heliyon.2019.e01300. eCollection 2019 Mar.

Venet T, Pichot V, Charier D, Scalabre A, Patural H. Autonomic cardiac regulation after general anesthesia in children. Paediatr Anaesth. 2018 Oct;28(10):881-887. doi: 10.1111/pan.13468.

Berger C, Casagranda L, Pichot V, Trombert-Paviot B, Faure-Conter C, Freycon C, Isfan F, Guichard I, Durieu I, Garcin A, Roche F, Patural H. Dysautonomia in Childhood Cancer Survivors: A Widely Underestimated Risk. J Adolesc Young Adult Oncol. 2018 Aug 23. doi: 10.1089/jayao.2018.0021. [Epub ahead of print]

Fauchon C, Pichot V, Faillenot I, Pommier B, Garcia-Larrea L, Peyron R, Chouchou F. Contextual modulation of autonomic pain reactivity. Auton Neurosci. 2018 Jul;212:28-31. doi: 10.1016/j.autneu.2018.04.002. Epub 2018 Apr 10.

Cremillieux C, Makhlouf A, Pichot V, Trombert B, Patural H. Objective assessment of induced acute pain in neonatology with the Newborn Infant Parasympathetic Evaluation index. Eur J Pain. 2018 Jul;22(6):1071-1079. doi: 10.1002/ejp.1191. Epub 2018 Mar 24.

Fauchon C, Faillenot I, Perrin AM, Borg C, Pichot V, Chouchou F, Garcia-Larrea L, Peyron R. Does an observer's empathy influence my pain ? Effect of perceived empathetic or unempathetic support in a pain test. Eur J Neurosci. 2017 Nov;46(10):2629-2637. doi: 10.1111/ejn.13701. Epub 2017 Oct 19.

Chouchou F, Bouet R, Pichot V, Catenoix H, Mauguière F, Jung J. The neural bases of ictal tachycardia in temporal lobe seizures. Clin Neurophysiol. 2017 Sep;128(9):1810-1819. 

Sforza E, Roche F, Barthélémy JC, Pichot V. Diurnal ans nocturnal cardiovascular variability and heart rate arousal response in idiopathic hypersomnia. Sleep Med. 2016 Aug;24:131-136.

Chalencon S, Pichot V, Roche F, Lacour JR, Garet M, Connes P, Barthélémy JC, Busso T. Modeling of performance and ANS activity for predicting future responses to training. Eur J Appl Physiol. 2015 Mar;115(3):589-96.

Sforza E, Pichot V, Gschwind M, Roche F, Maeder-Ingvar M. Bradycardia and asystole during generalised interictal EEG discharges. Epileptic Disord. 2014 Dec;16(4):506-9.

Chouchou F, Pichot V, Barthélémy JC, Bastuji H, Roche F. Cardiac sympathetic modulation in response to apneas/hypopneas through heart rate variability analysis. PLoS One. 2014 Jan 22;9(1).

Chouchou F, Pichot V, Pépin JL, Tamisier R, Celle S, Maudoux D, Garcin A, Lévy P, Barthélémy JC, Roche F; PROOF Study Group. Sympathetic overactivity due to sleep fragmentation is associated with elevated diurnal systolic blood pressure in healthy elderly subjects: the PROOF-SYNAPSE study. Eur Heart J. 2013;34(28):2122-31.

Chalencon S, Busso T, Lacour JR, Garet M, Pichot V, Connes P, Gabel CP, Roche F, Barthélémy JC. A model for the training effects in swimming demonstrates a strong relationship between parasympathetic activity, performance and index of fatigue. PLoS One. 2012;7(12).

Sforza E, Chouchou F, Pichot V, Barthélémy JC, Roche F. Heart rate increment in the diagnosis of obstructive sleep apnoea in an older population. Sleep Med. 2012 Jan;13(1):21-8.

Chouchou F, Pichot V, Perchet C, Legrain V, Garcia-Larrea L, Roche F, Bastuji H. Autonomic pain responses during sleep: a study of heart rate variability. Eur J Pain. 2011 Jul;15(6):554-60.

Assoumou HG, Pichot V, Barthelemy JC, Dauphinot V, Celle S, Gosse P, Kossovsky M, Gaspoz JM, Roche F. Metabolic syndrome and short-term and long-term heart rate variability in elderly free of clinical cardiovascular disease: the PROOF study. Rejuvenation Res. 2010;13(6):653-63.

Chouchou F, Pichot V, Garet M, Barthélémy JC, Roche F. Dominance in cardiac parasympathetic activity during real recreational SCUBA diving. Eur J Appl Physiol. 2009 Jun;106(3):345-52

Patural H, Pichot V, Jaziri F, Teyssier G, Gaspoz JM, Roche F, Barthelemy JC. Autonomic cardiac control of very preterm newborns: a prolonged dysfunction. Early Hum Dev. 2008 Oct;84(10):681-7.

Sforza E, Pichot V, Cervena K, Barthélémy JC, Roche F. Cardiac variability and heart-rate increment as a marker of sleep fragmentation in patients with a sleep disorder: a preliminary study. Sleep. 2007 Jan;30(1):43-51.

Roche F, Celle S, Pichot V, Barthélémy JC, Sforza E. Analysis of the interbeat interval increment to detect obstructive sleep apnoea/hypopnoea. Eur Respir J. 2007 Jun;29(6):1206-11.

Garet M, Degache F, Pichot V, Duverney D, Costes F, DA Costa A, Isaaz K, Lacour JR, Barthélémy JC, Roche F.Relationship between daily physical activity and ANS activity in patients with CHF. Med Sci Sports Exerc. 2005 Aug;37(8):1257-63.

Pichot V, Roche F, Denis C, Garet M, Duverney D, Costes F, Barthélémy JC. Interval training in elderly men increases both heart rate variability and baroreflex activity. Clin Auton Res. 2005;15(2):107-15.

Patural H, Barthelemy JC, Pichot V, Mazzocchi C, Teyssier G, Damon G, Roche F. Birth prematurity determines prolonged autonomic nervous system immaturity. Clin Auton Res. 2004 Dec;14(6):391-5.

Roche F, Pichot V, Sforza E, Court-Fortune I, Duverney D, Costes F, Garet M, Barthélémy JC. Predicting sleep apnoea syndrome from heart period: a time-frequency wavelet analysis. Eur Respir J. 2003 Dec;22(6):937-42.

Pichot V, Busso T, Roche F, Garet M, Costes F, Duverney D, Lacour JR, Barthélémy JC. Autonomic adaptations to intensive and overload training periods: a laboratory study. Med Sci Sports Exerc. 2002 Oct;34(10):1660-6.

Pichot V, Gaspoz JM, Molliex S, Antoniadis A, Busso T, Roche F, Costes F, Quintin L, Lacour JR, Barthélémy JC. Wavelet transform to quantify heart rate variability and to assess its instantaneous changes. J Appl Physiol (1985). 1999 Mar;86(3):1081-91.

Principal references from our group linked to CVRanalysis software

Assoumou HG, Bertholon F, Barthelemy JC, Pichot V, Celle S, Gosse P, Gaspoz JM, Roche F. Alteration of baroreflex sensitivity in the elderly: The relationship with metabolic syndrome components. International journal of cardiology. 2012;155:333-335

Costes F, Roche F, Pichot V, Vergnon JM, Garet M, Barthelemy JC. Influence of exercise training on cardiac baroreflex sensitivity in patients with copd. The European respiratory journal. 2004;23:396-401

Crawford-Achour E, Roche F, Pichot V, Celle S, Barthelemy JC, Chouchou F. Sleep-related autonomic overactivity in a general elderly population and its relationship to cardiovascular regulation. Heart and vessels. 2016;31:46-51

Dauphinot V, Kossovsky MP, Gueyffier F, Pichot V, Gosse P, Roche F, Barthelemy JC. Impaired baroreflex sensitivity and the risks of new-onset ambulatory hypertension, in an elderly population-based study. International journal of cardiology. 2013;168:4010-4014

Pichot V, Roche F, Denis C, Garet M, Duverney D, Costes F, Barthelemy JC. Interval training in elderly men increases both heart rate variability and baroreflex activity. Clinical autonomic research : official journal of the Clinical Autonomic Research Society. 2005;15:107-115

Roche F, Reynaud C, Garet M, Pichot V, Costes F, Barthelemy JC. Cardiac baroreflex control in humans during and immediately after brief exposure to simulated high altitude. Clinical physiology and functional imaging. 2002;22:301-306

Saint Martin M, Roche F, Thomas-Anterion C, Barthelemy JC, Sforza E. Eight-year parallel change in baroreflex sensitivity and memory function in a sample of healthy older adults. Journal of the American Geriatrics Society. 2015;63:270-275

Saint Martin M, Sforza E, Thomas-Anterion C, Barthelemy JC, Roche F. Baroreflex sensitivity, vascular risk factors, and cognitive function in a healthy elderly population: The proof cohort. Journal of the American Geriatrics Society. 2013;61:2096-2102